Resistell’s rapid AST diagnostic method is based on the detection of movement caused by living bacterial cells. We use cantilevers, also used in Atomic Force Microscopy, as sensors. Our device is much simpler and cheaper than commercial AFM because all optics have been removed.
Living bacteria cause the cantilevers’ oscillations, which can be detected by our device. When antibiotic is added, bacteria react and the cantilever’s vibrations return to the level of an abiotic sample (a sample without bacteria) within minutes.
Laser and photodiode are used to detect the cantilever’s movement. The custom made software is used to process the signal and classify the strain as susceptible or resistant.