Phenotech Research

Phenotech Research provides completely new insights into the health and functioning of cells. It measures cellular vibrations at the nanoscale level; independent of growth or reporter systems. Allowing for swift test results and the study of previously non or hardly accessible growth phenotypes, encompassing VBNCs (viable but non-culturable cells) and persister cells. The open system frees researchers from specific frameworks, facilitating new and creative research models with unlimited use cases. Discover more than ever, faster than before with Phenotech Research - where tiny vibrations lead to great revelations.

Fig: Phenotech Research

Multiple applications

Phenotech device applies

Blood Stream Infections

(Enterobacteriaceae)

Urinary Tract Infections

(Enterobacteriaceae)

Tuberculosis¹

(Mycobacterium tuberculosis)

Phage Therapy

Personalized Cancer Therapy²

Antifungal Testing³

(Candida albicans)

Stomach Ulcers

(Helicobacter pylori)

Sexually Transmitted Diseases

(Chlamydia trachomatis)

1) Vocat et al. Microbes and Infection 2023

2) Venturelli et al. J Mol Recognit. 2020, e2849

3) Kasas et al. PNAS 2015, 112, 378–381; Kohler et al. Fermentation 2020, 6, 28.

Features

Cutting-edge phenotypic technology for measuring cell metabolism based on cellular vibrations
Real-time monitoring with continuous, high-frequency measurements
Independent of molecular reporter systems, probes or dyes, leading to simple non-disruptive measurements
Applicable to many microbes, encompassing Gram-negative and Gram-positive bacteria, mycobacteria, fungi, and yeast
Adaptable test conditions with easy exchange of media and drug conditions
Fast and easy sample preparation with Resistell kit
Automated analysis and data processing software

Technology

Cantilever sensors versus superbugs

The Resistell technology platform utilises micro-mechanical sensors to measure nanomotion of living cells. The oscillations of bacteria at the nanoscale are compared before and after the use of antibiotics. When the bacteria cease to move, it means that the antibiotic has eliminated it and is therefore effective. The platform employs advanced machine learning (ML) to develop classification models for different susceptibility phenotypes.

Multiple applications

Features

Technology

Our patented nanomotion technology platform includes

Hardware

Software